CSC

	Tehdyt toimenpiteet University of Kuopio Department of Neurobiology, A.I. Virtanen Institute Group leader: Gary Wong Home page: http://www.uku.fi/aivi/neuro/index_genomics.shtml Research Interests: Microarray Gene Expression Analysis - project for analyzing and extracting the vital information from the massive amounts of data produced by microarrays. Applications from the neurobiology of disease, pharmacology, and model systems are used as input data. Various clustering algorithms are used including heierarchial clustering and self-organizing-maps, a neuron based machine learning algorithm. Production of Bioinformatic Tools for Processing Gene Lists - gene lists are produced from microarray, RNAinterference, proteomics and other genomics studies. The gene lists are analyzed for over representation of thematic groups based on gene ontologies. Web-enabled implementations are developed for users that arise from algorithms developed in the laboratory. Integrated Visualization Platform - publically available and our own laboratory written bioinformatic data analysis tools are gathered and a data analysis pipeline is constructed from these tools. Data formatting and visualization applications are produced in order to provide users ability to gather, analyze, and interpret biological data from diverse (e.g. sequence, microarray, proteomic, chromosome localization) sources. C. Elegans as a model system for studying human neurodegenerative diseases - transgenic worm models are produced to understand the molecular and celluar events leading to neurodegeneration. Various putative or candidate neurotoxicity causing genes are over expressed in worms using coexpression of green-fluorescent protein (GFP) in neurons as a marker, followed by fluorescent microscopy. Various worm phenotypes are scored and characterized Back to the group list