CSC

	Tehdyt toimenpiteet Jurilab Oy Bioinformatics contact person: Pekka Uimari Home page: http://www.jurilab.com/ Jurilab develops genetic tests for Finnish national diseases, like cardiovascular diseases and also searches for potential drug targets. Jurilab's bioinformatics efforts can be separated into two main phases. The first phase utilizes statistical genetics, i.e., the linkage between DNA markers and a disease is analyzed. In this area, Jurilab has been in collaboration with the HIIT (Prof. Toivonen) within the Tekes-funded Altti project. From one patient 100 000 SNP markers can be analyzed simultaneously (in the future the number of markers will increase to 500 000). This makes data management essential. Jurilab has used the BC Gene database system from Biocomputing Platforms Ltd, which has been developed for effective management of this kind of datasets. Using statistical methods, a set of SNP markers and corresponding genes are selected for more detailed in silico analysis. This is done mainly manually, by, e.g., studying the genome annotation and connection between genes. Automatized tools for this phase are being developed in the Tekes-funded Biomine project (in collaboration with prof. Toivonen from University of Helsinki). In addition Jurilab has done some collaboration with Prof. Carlberg (University of Kuopio) for detecting nuclear receptors from a genome. Back to the group list